Why the study?
HCM development involves dysregulation of gene expression, but because one miRNA regulates several target genes post-transcriptionally, determining the role of a particular miRNA in disease pathogenesis is difficult.
Population
15 miRNAs associated with myocardial fibrosis in HCM
Design
In silico bioinformatic analysis
Authors
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Does not yet inform hypertrophic cardiomyopathy management; leaves open TGF-β/SMAD as a miRNA-regulated target for future antifibrotic research.
In silico analysis reveals that miRNAs associated with myocardial fibrosis in hypertrophic cardiomyopathy predominantly regulate the TGF-β/SMAD signaling pathway, highlighting its key role in the disease pathogenesis.
Pisklova et al. (2022) studied this question.
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