Population
750 myopathy patients presenting to the Johns Hopkins Myositis Center, as well as in vitro cultured cells…
Design
Cohort
Authors
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Anti-HMGCR testing may support diagnosis in statin-exposed myopathy; leaves open need for prospective validation before changing practice.
Statins up-regulate HMGCR, which is the major autoantigen in statin-associated immune-mediated necrotizing myopathy, providing a mechanistic link between statin exposure and sustained autoimmunity.
Mammen et al. (2010) studied this question.
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