What is the clinical evidence from this study?

Study design: Review. Population: Pregnancy-related venous thromboembolism. Intervention: Low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH).

What question did this study set out to answer?

To assess the incidence and risk factors associated with venous thromboembolism during pregnancy and to evaluate the effectiveness of anticoagulation therapies.

April 17, 2014Journal of Pharmacy Practice

Pregnancy-Related Venous Thromboembolism

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Key result

Pregnancy is linked to increased VTE risk, occurring in ~0.2% of deliveries.

Key Points

To assess the incidence and risk factors associated with venous thromboembolism during pregnancy and to evaluate the effectiveness of anticoagulation therapies.
Reviewed incidence rates of VTE in pregnancy from various studies
Identified risk factors such as advanced maternal age, obesity, and history of VTE
Evaluated the efficacy of LMWH and UFH for anticoagulation during pregnancy.
Incidence of VTE in pregnancy is reported at 0.49 to 2 events per 1000 deliveries.
Women with a history of VTE have a 4-fold increased risk of recurrence in subsequent pregnancies.
LMWH is preferred over UFH due to lower adverse event rates.

Structured PICO

Population

Pregnant women, including those with risk factors such as advanced maternal age, obesity, smoking, cesarian section, previous VTE, or thrombophilia

Intervention

Anticoagulation with low-molecular-weight heparin (LMWH) or unfractionated heparin (UFH)

LMWH is the preferred anticoagulant for managing the increased risk of venous thromboembolism during pregnancy.

Authors

EAEmily M. ArmstrongAuburn University JBJessica M. BelloneSanofi (United States)LHLori B. HornsbyAuburn University

Discussion

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Implication

Raises VTE awareness in pregnancy; confirms incidence estimates but leaves prophylaxis optimization open for prospective trials.

Cite This Study

Armstrong et al. (2014) conducted a review in Pregnancy-related venous thromboembolism. Low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) was evaluated. Pregnancy is associated with an increased risk of venous thromboembolism, with a reported incidence ranging from 0.49 to 2 events per 1000 deliveries.

synapsesocial.com/papers/6a0fbfeb96ccf432805fc308 https://doi.org/10.1177/0897190014530425

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Pregnancy-Related Venous Thromboembolism

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Pregnancy-Related Venous Thromboembolism

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider