Molecular dynamics simulation research on the interaction between plasma and living organisms: A comprehensive review

In recent years, plasma biomedicine has developed into a new interdisciplinary subject. The interaction between plasma and organisms involves three aspects: “gas–liquid–living organisms.” Molecular dynamics (MD) simulation can simulate the interaction process between plasma and biological tissue with high temporal and spatial resolution. This article reviews the research on plasma biomedicine based on MD simulation and systematically summarizes the progress of MD simulation research on the interaction between plasma and water layer, cell membrane, intracellular substances, extracellular environment, and viruses. These simulations offer a unique opportunity to gain insights into the microscopic mechanisms of these interactions. This article also further looks forward to the opportunities and challenges of MD simulation research.