What question did this study set out to answer?

Summarize the systemic metabolic properties and electrolyte-regulating actions of progesterone beyond its classical role in female reproductive physiology.

October 1, 1955The Journal of Clinical Endocrinology & Metabolism

The Metabolic Effects of Progesterone in Man*†

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Authors

RLRichard L. LandauMassachusetts Institute of Technology DBDelbert M. BergenstalMay Institute KLKathleen LugibihlUniversity of Chicago

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Implication

Review demonstrates conflicting anabolic and catabolic systemic responses to progesterone in humans, suggesting complex tissue-dependent metabolic regulation.

Key Points

Summarize the systemic metabolic properties and electrolyte-regulating actions of progesterone beyond its classical role in female reproductive physiology.
Synthesized findings from animal models evaluating survival, work capacity, and mineral retention following adrenalectomy and progesterone administration.
Reviewed clinical observations in Addison's disease and healthy male subjects receiving daily progesterone doses ranging from 30 mg to 100 mg.
Progesterone acts as a life-preserving and salt-retaining steroid in adrenalectomized animals at 10 to 20 mg daily, but 30 mg daily produced no change in urinary chloride excretion in a man with Addison's disease.
Responses show tissue-specific divergence, stimulating anabolic growth in rodent sebaceous glands while producing a net catabolic effect in healthy human subjects given 100 mg daily.

Cite This Study

Landau et al. (1955) studied this question.

synapsesocial.com/papers/6a0fc8018090e499da602a61 https://doi.org/10.1210/jcem-15-10-1194

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Implication

Review demonstrates conflicting anabolic and catabolic systemic responses to progesterone in humans, suggesting complex tissue-dependent metabolic regulation.

The Metabolic Effects of Progesterone in Man*†

Discussion

Member takes

Implication

Key Points

Cite This Study

The Metabolic Effects of Progesterone in Man*†

Discussion

Member takes

Implication

Key Points

Cite This Study

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