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May 1, 2008Canadian Journal of Neurological Sciences / Journal Canadien des Sciences NeurologiquesOpen Access

Effect of Ximelagatran and Warfarin on Stroke Subtypes in Atrial Fibrillation

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Why the study?

Does ximelagatran prevent cardioembolic and noncardioembolic strokes as effectively as warfarin in patients with nonvalvular atrial fibrillation?

Population

7,329 patients with nonvalvular atrial fibrillation and ≥1 risk factors for stroke

Comparison

Fixed-dose ximelagatran vs Warfarin

Design

RCT, Randomized to treatment

Authors

JTJeanne TeitelbaumMontreal Neurological Institute and HospitalRKRüdiger von KummerUniversity Hospital Carl Gustav CarusKGKnut GjesdalElectrophysiology

Discussion

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Overview

Ximelagatran matches warfarin for preventing both cardioembolic and noncardioembolic strokes in NVAF; confirms RCT equivalence for these endpoints.

Structured PICO

Does ximelagatran prevent cardioembolic and noncardioembolic strokes as effectively as warfarin in patients with nonvalvular atrial fibrillation?

P
Population
7,329 patients with nonvalvular atrial fibrillation and ≥1 risk factors for stroke
I
Intervention
Fixed-dose ximelagatran (oral direct thrombin inhibitor)
C
Comparator
Warfarin (target international normalized ratio 2.0-3.0)
O
Outcome
Risk and outcome of cardioembolic and noncardioembolic strokehard clinical

Ximelagatran and warfarin demonstrated similar efficacy in preventing both cardioembolic and noncardioembolic strokes in patients with nonvalvular atrial fibrillation.

Cite This Study

Teitelbaum et al. (2008) studied this question.

synapsesocial.com/papers/6a0fcb229e54838161fd3324https://doi.org/10.1017/s031716710000857x

Topics

Atrial fibrillationPersistent AF managementAnticoagulation in AF
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stroke Prevention Using the Oral Direct Thrombin Inhibitor Ximelagatran in Patients with Non-Valvular Atrial Fibrillation2006 · 101 citations
  2. 2Antithrombotic Therapy To Prevent Stroke in Patients with Atrial Fibrillation1999 · 1,648 citations
  3. 3Ischemic stroke in patients with atrial fibrillation1993 · 156 citations
  4. 4Atrial fibrillation and stroke. Three new studies, three remaining questions1994 · 169 citations
  5. 5Atrial Fibrillation and Stroke1994 · 145 citations