What question did this study set out to answer?

Determine whether haemodialysis-induced prolongation of QTc dispersion predicts life-threatening cardiovascular events and mortality in patients with cardiac complications.

April 1, 2005NephrologyOpen Access

QTc dispersion in haemodialysis patients with cardiac complications

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Why the study?

Does prolongation of QTc dispersion after haemodialysis predict cardiovascular events and deaths in patients with renal failure and cardiac complications?

Key Points

Determine whether haemodialysis-induced prolongation of QTc dispersion predicts life-threatening cardiovascular events and mortality in patients with cardiac complications.
Enrolled 48 chronic haemodialysis patients with cardiac symptoms (32 with chest pain, 2 with arrhythmia, 14 with heart failure; 40 males, 8 females), including 26 with angiographically confirmed ischaemic heart disease.
Assessed standard 12-lead electrocardiograms before and after haemodialysis, followed by prospective monitoring over 37 ± 24 months.
Over the follow-up period, 30 patients experienced cardiac events and 23 total deaths occurred, including 18 cardiovascular deaths.
Patients who exhibited post-haemodialysis prolongation of QTc dispersion experienced a higher incidence of cardiovascular death compared to those without prolongation.

Structured PICO

Does prolongation of QTc dispersion after haemodialysis predict cardiovascular events and deaths in patients with renal failure and cardiac complications?

Population

48 patients receiving chronic haemodialysis with cardiac symptoms (chest pain n=32, arrhythmia n=2, heart failure n=14), 40 males and 8 females. 26 had ischaemic heart disease, 10 had cerebrovascular accidents, and 11 had peripheral vascular disease.

Intervention

Prolongation of QTc dispersion after haemodialysis treatment

Comparator

No prolongation of QTc dispersion after haemodialysis treatment

Outcome

Cardiovascular events and related deathshard clinical

Prolongation of QTc dispersion after haemodialysis is a predictor of cardiovascular death in patients with renal failure and cardiac complications.

Discussion

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Implication

May warrant closer surveillance in high-risk dialysis patients; leaves open incremental prognostic value beyond standard markers.

Cite This Study

Nakamura et al. (2005) studied this question.

synapsesocial.com/papers/6a0fcb7bd12fb77703193c98 https://doi.org/10.1111/j.1440-1797.2005.00362.x

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QTc dispersion in haemodialysis patients with cardiac complications

Key Points

Structured PICO

Discussion

Implication

Cite This Study

QTc dispersion in haemodialysis patients with cardiac complications

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider