Why the study?
High-level endurance athletes show increased AF incidence rivaling cardiovascular disease patients, suggesting a J-shaped relationship that motivated investigating the dependence of AF vulnerability on exercise dose.
Does prolonged daily exercise duration increase atrial fibrillation vulnerability and adverse atrial remodeling in mice?
Population
7-week-old male CD1 mice
Comparison
Daily swim durations of 120 vs 180 vs 240 min day –1
Design
Preclinical animal study
Follow-up
6 weeks
Authors
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May increase AF risk with extreme endurance volumes in mice; leaves open human translation and mechanisms.
Does prolonged daily exercise duration increase atrial fibrillation vulnerability and adverse atrial remodeling in mice?
Prolonged daily endurance exercise in mice drives adverse atrial-specific remodeling and vagal-dependent AF vulnerability despite beneficial ventricular and skeletal muscle adaptations.
Gorman et al. (2024) studied this question.
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