Key result
High fasting plasma insulin linked to ~31% lower incident AF risk.
Why the study?
Is fasting plasma insulin associated with the incidence of atrial fibrillation in a middle-aged population?
Population
7,066 middle-aged subjects (6,052 men and 1,014 women) from the Malmö preventive project cohort
Comparison
Fasting plasma insulin (FPI) levels vs Lower levels of fasting plasma insulin
Design
Cohort
Follow-up
average 26.2 years
Authors
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Higher insulin should not yet inform AF risk assessment; leaves open metabolic effects on arrhythmia incidence in observational cohorts.
Cohort (n=7,066)
No
Is fasting plasma insulin associated with the incidence of atrial fibrillation in a middle-aged population?
Effect estimate: HR 0.69 (95% CI 0.57-0.83)
p-value: p=<0.0001
Higher fasting plasma insulin levels are associated with a lower risk of incident atrial fibrillation over long-term follow-up, particularly in men.
Johnson et al. (2014) conducted a cohort in Atrial fibrillation (n=7,066). Fasting plasma insulin (4th quartile) vs. Fasting plasma insulin (1st quartile) was evaluated on Incident atrial fibrillation (HR 0.69, 95% CI 0.57-0.83, p=<0.0001). High levels of fasting plasma insulin were associated with a significantly lower risk of incident atrial fibrillation (HR 0.69) compared to the lowest quartile in a middle-aged cohort.
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