February 14, 2013Circulation Arrhythmia and ElectrophysiologyOpen Access

Role of Leptin Signaling in the Pathogenesis of Angiotensin II–Mediated Atrial Fibrosis and Fibrillation

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Structured PICO

Population

Eight-week-old male CL57/B6 (CNT) and leptin-deficient ob/ob mice (Ob); left-atrial fibroblasts isolated from adult Sprague-Dawley and Zucker rats.

Intervention

Angiotensin II (2.0 mg/kg per day) subcutaneous infusion for 2 weeks (in vivo); leptin (100 ng/mL) or AngII (100 nmol/L) treatment (in vitro).

Comparator

Leptin-deficient ob/ob mice vs wild-type CL57/B6 mice; Zucker rat fibroblasts vs Sprague-Dawley rat fibroblasts.

Outcome

Induction of atrial fibrillation by transesophageal burst pacing and isolated perfused heart electrophysiological study; interstitial fibrosis and profibrotic mRNA expression.surrogate

Leptin signaling is essential for the development of Angiotensin II-induced atrial fibrosis and atrial fibrillation in preclinical models.

Discussion

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Implication

Hypothesis-generating that leptin mediates AngII AF in mice; leaves open human relevance and therapeutic targeting.

Cite This Study

Fukui et al. (2013) studied this question.

synapsesocial.com/papers/6a0fccd22badbc352afebc56 https://doi.org/10.1161/circep.111.000104

Topics

Atrial fibrillation Persistent AF management

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Role of Leptin Signaling in the Pathogenesis of Angiotensin II–Mediated Atrial Fibrosis and Fibrillation

Structured PICO

Discussion

Implication

Cite This Study

Topics

Role of Leptin Signaling in the Pathogenesis of Angiotensin II–Mediated Atrial Fibrosis and Fibrillation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider