Key result
A 25% increase in fasting glucose was associated with a 5.8% decrease in arterial compliance (95% CI, -9.6% to -1.9%; P=0.004) in nondiabetic white men and a 15.0% decrease in white women.
Why the study?
Are elevated fasting glucose and insulin concentrations associated with increased arterial stiffness in adults aged 45 to 64?
Population
Biracial sample of 4701 men and women 45 to 64 years of age in the Atherosclerosis Risk in Communities Study
Comparison
Elevated fasting glucose and serum insulin… vs Normal glucose tolerance / lower fasting glucose…
Design
Cross-sectional
Authors
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May identify early vascular risk in nondiabetics; hypothesis-generating for glucose-arterial stiffness causality.
Cross-Sectional (n=4,701)
Yes
Are elevated fasting glucose and insulin concentrations associated with increased arterial stiffness in adults aged 45 to 64?
Elevated fasting glucose and insulin concentrations are synergistically associated with increased arterial stiffness independent of artery wall thickness, highlighting their role in the early pathophysiology of macrovascular disease.
Salomaa et al. (1995) conducted a cross-sectional in Non-insulin-dependent diabetes mellitus and impaired glucose tolerance (n=4,701). Fasting glucose and insulin concentrations was evaluated on Arterial stiffness indexes (arterial compliance, stiffness index, pressure-strain elastic modulus, and Young's elastic modulus). A 25% increase in fasting glucose was associated with a 5.8% decrease in arterial compliance (95% CI, -9.6% to -1.9%; P=0.004) in nondiabetic white men and a 15.0% decrease in white women.