What question did this study set out to answer?

Characterize the structural organization, sequence conservation, and evolutionary relationships across the annexin super-gene family.

June 1, 1991European Journal of Biochemistry

Amino acid sequence analysis of the annexin super‐gene family of proteins

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Characterize the structural organization, sequence conservation, and evolutionary relationships across the annexin super-gene family.
Analyzed 22 available annexin protein sequences comprising 88 repeat units using multiple sequence alignment, pattern matching, secondary structure prediction, and conservation analysis.
Evaluated predicted secondary and tertiary structural properties and re-evaluated predictions against published human annexin V X-ray crystallographic data.
Repeat units clustered into four distinct families, with repeat 3 displaying the greatest sequence variation and Gly at position 23 being the only absolutely conserved residue across all 88 repeats.
Identified five conserved alpha-helices per repeat unit with specific hydrophobic packing patterns, as well as a repeat-specific Arg-Glu pair indicative of a buried salt bridge between repeats 2 and 4.
Found no compelling structural evidence linking annexins to uteroglobin, while newly published X-ray crystallography of human annexin V validated the sequence-based structural predictions.

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Implication

Sequence analysis reveals conserved structural motifs across annexin repeats, highlighting critical inter-repeat interactions and folding organization.

Cite This Study

Barton et al. (1991) studied this question.

synapsesocial.com/papers/6a0fd84601be78fe816017fd https://doi.org/10.1111/j.1432-1033.1991.tb16076.x

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Implication

Sequence analysis reveals conserved structural motifs across annexin repeats, highlighting critical inter-repeat interactions and folding organization.

Amino acid sequence analysis of the annexin super‐gene family of proteins

Key Points

Discussion

Implication

Cite This Study

Amino acid sequence analysis of the annexin super‐gene family of proteins

Key Points

Discussion

Implication

Cite This Study

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