Why the study?
Use of the Melody valve in the aortic position is rarely reported, with only one prior description in a patient with hypoplastic left heart syndrome.
Transcatheter Melody valve placement is technically feasible to treat severe neoaortic stenosis in adult HLHS patients with Fontan circulation, though durability in this high-pressure position remains questionable.
May support Melody valve use in adult HLHS Fontan patients; leaves open durability, safety, and need for prospective data.
The Melody valve (Medtronic) is commonly used for pulmonary valve replacement in patients with dysfunctional right ventricle to pulmonary artery conduits or bioprosthetic pulmonary valves. Rare reports exist of its use in the aortic position, including only 1 prior description of its use in a patient with hypoplastic left heart syndrome. We describe a 31-year-old patient with hypoplastic left heart syndrome who had severe neoaortic valve stenosis and moderate regurgitation that was successfully treated with percutaneous Melody valve placement in the neoaortic position.
No takes yet. Share an insight, caveat, or question.
Schwartz et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: