July 1, 2008Circulation
Outcome of Alcohol Septal Ablation for Obstructive Hypertrophic Cardiomyopathy
Why the study?
Does alcohol septal ablation improve survival and symptoms compared to septal myectomy in patients with severely symptomatic obstructive hypertrophic cardiomyopathy?
Population
138 patients with severely symptomatic drug-refractory obstructive hypertrophic cardiomyopathy, median age…
Comparison
Alcohol septal ablation vs Age- and gender-matched patients who underwent…
Design
Cohort
Follow-up
4 years
Authors
Discussion
Loading...
Member takes
Implication
May offer similar survival to myectomy with higher complications; leaves open optimal septal reduction strategy pending randomized trials.
Structured PICO
Does alcohol septal ablation improve survival and symptoms compared to septal myectomy in patients with severely symptomatic obstructive hypertrophic cardiomyopathy?
P
Population
138 patients with severely symptomatic drug-refractory obstructive hypertrophic cardiomyopathy, median age 64 years, 39% men.
I
Intervention
Alcohol septal ablation
C
Comparator
Age- and gender-matched patients who underwent septal myectomy
O
Outcome
Four-year survival free of all mortalityhard clinical
Alcohol septal ablation offers similar 4-year survival to myectomy for obstructive hypertrophic cardiomyopathy, but carries a higher procedural complication rate, particularly for pacemaker implantation.
Limitations
- Nonrandomized study
- Long-term outcome remains unknown
Cite This Study
Sorajja et al. (2008) studied this question.