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November 13, 2006European Heart JournalOpen Access

Septal ablation in hypertrophic obstructive cardiomyopathy improves systolic myocardial function in the lateral (free) wall: a follow-up study using CMR tissue tagging and 3D strain analysis

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Why the study?

Does alcohol septal ablation improve regional myocardial function and mass in patients with symptomatic hypertrophic obstructive cardiomyopathy?

Population

9 patients with symptomatic hypertrophic obstructive cardiomyopathy (HOCM), mean age 52+/-15 years

Comparison

Alcohol septal ablation (ASA) vs Baseline (pre-procedure)

Design

Cohort

Follow-up

6 months

Authors

WDWillem G. van DockumJKJoost P.A. KuijerMGMarco Götte

Discussion

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Member takes

Overview

Associated with remote myocardial improvement post-ASA; leaves open whether this drives clinical benefit versus myectomy.

Structured PICO

Does alcohol septal ablation improve regional myocardial function and mass in patients with symptomatic hypertrophic obstructive cardiomyopathy?

P
Population
9 patients with symptomatic hypertrophic obstructive cardiomyopathy (HOCM), mean age 52+/-15 years
I
Intervention
Alcohol septal ablation (ASA)
C
Comparator
Baseline (pre-procedure)
O
Outcome
Regional myocardial function (shortening index and shortening index rate) and regional myocardial mass measured by CMR tissue tagging and 3D strain analysis at 6 monthssurrogate

Alcohol septal ablation in symptomatic HOCM reduces myocardial mass and improves systolic function in the remote lateral wall at 6 months, indicating reversed LV remodeling.

Cite This Study

Dockum et al. (2006) studied this question.

synapsesocial.com/papers/6a0fdd185725bbd5cc602b8chttps://doi.org/10.1093/eurheartj/ehl358
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