May 1, 1988CirculationOpen Access

Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart.

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Population

Isolated perfused pig hearts

Comparison

Induction of regional ischemia, global ischemia… vs Normal zone or different ischemic conditions

Design

Preclinical

Authors

RCRuben CoronelTulane University JFJ W FioletAmsterdam UMC Location University of Amsterdam FWF.J.G. Wilms-SchopmanNetherlands Heart Institute

Discussion

Member takes

Implication

May refine ECG analysis in acute ischemia; leaves open translation to human arrhythmia risk stratification.

Structured PICO

Population

Isolated perfused pig hearts

Intervention

Induction of regional ischemia, global ischemia, and perfusion with high-K perfusate

Comparator

Normal zone or different ischemic conditions

Outcome

Extracellular potassium concentration ([K+]out) and local direct-current electrograms (TQ depression)surrogate

This preclinical study demonstrates that extracellular potassium inhomogeneity is greatest in the ischemic borderzone and correlates locally with TQ segment depression.

Cite This Study

Coronel et al. (1988) studied this question.

synapsesocial.com/papers/6a0fdd4e4fb650da4ffe976a https://doi.org/10.1161/01.cir.77.5.1125

View Full Paper

Ask AI

Bookmark

Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider