What question did this study set out to answer?

To examine whether nonfasting serum insulin and components of the insulin resistance syndrome mediate the relationship between physical activity and incidence of coronary heart disease and type 2 diabetes.

July 24, 2000Archives of Internal Medicine

Physical Activity, Metabolic Factors, and the Incidence of Coronary Heart Disease and Type 2 Diabetes

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Authors

SWS. Goya WannametheePreventive Cardiology ASA G ShaperUniversity College London KAK. G. M. M. AlbertiImperial College London

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Implication

Prospective study reveals physical activity differentially lowers coronary heart disease and diabetes risk in middle-aged men, indicating insulin pathways mediate only diabetes protection.

Key Points

To examine whether nonfasting serum insulin and components of the insulin resistance syndrome mediate the relationship between physical activity and incidence of coronary heart disease and type 2 diabetes.
Prospective cohort study of 5159 men aged 40 to 59 years without baseline coronary heart disease, type 2 diabetes, or stroke recruited from general practices in 18 British towns.
Participants were followed over an average duration of 16.8 years to identify incident type 2 diabetes and fatal or nonfatal coronary heart disease events.
Over the 16.8-year follow-up, 616 major coronary heart disease events and 196 incident cases of type 2 diabetes occurred.
Physical activity was inversely associated with coronary heart disease, reaching lowest risk at moderate activity levels, whereas type 2 diabetes risk declined progressively with higher activity.
Statistical adjustment for serum insulin, blood pressure, high-density lipoprotein cholesterol, and gamma-glutamyltransferase largely explained diabetes risk reduction, but had minimal effect on coronary heart disease risk.

Cite This Study

Wannamethee et al. (2000) studied this question.

synapsesocial.com/papers/6a0fdec792676d5461fd2ec6 https://doi.org/10.1001/archinte.160.14.2108

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Implication

Prospective study reveals physical activity differentially lowers coronary heart disease and diabetes risk in middle-aged men, indicating insulin pathways mediate only diabetes protection.

Physical Activity, Metabolic Factors, and the Incidence of Coronary Heart Disease and Type 2 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Physical Activity, Metabolic Factors, and the Incidence of Coronary Heart Disease and Type 2 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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