Key result
Inhibition of Gi signaling using the GiCT peptide in transgenic mice significantly increased infarct size compared with nontransgenic mice (50.9% vs 36.9%) following ischemia/reperfusion injury.
Why the study?
Does targeted inhibition of cardiomyocyte Gi signaling increase infarct size in mice subjected to ischemia/reperfusion injury?
Does targeted inhibition of cardiomyocyte Gi signaling increase infarct size in mice subjected to ischemia/reperfusion injury?
Absolute Event Rate: 50.9% vs 36.9%
Inhibition of cardiomyocyte Gi signaling exacerbates ischemia/reperfusion injury, indicating that G alpha(i2) upregulation is a protective adaptive response.
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Gi signaling may protect against ischemia/reperfusion injury; leaves open whether Gαi2 modulation could reduce infarct size in patients.
DeGeorge et al. (2008) studied Ischemia/reperfusion injury. GiCT (Gi inhibitor peptide) vs. Nontransgenic mice was evaluated on Infarct size. Inhibition of Gi signaling using the GiCT peptide in transgenic mice significantly increased infarct size compared with nontransgenic mice (50.9% vs 36.9%) following ischemia/reperfusion injury.
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