Coronary artery calcium scoring is strongly associated with an increased risk of non-cardiovascular diseases and all-cause mortality, highlighting its potential in early diagnosis and prognosis.
Does coronary artery calcium scoring predict the risk of non-cardiovascular diseases and all-cause mortality in asymptomatic individuals?
Coronary artery calcium scoring, traditionally used for cardiovascular risk stratification, also demonstrates a strong predictive association with a wide range of non-cardiovascular diseases and all-cause mortality.
Coronary artery calcium scoring (CACS), a non-invasive measure of coronary atherosclerosis, has significantly enhanced cardiovascular (CV) risk assessment and stratification in asymptomatic individuals. More recently, a higher score for CAC has been associated with an increased risk of non-CV diseases and all-cause mortality. This review consolidated evidence supporting the role of CAC in assessing non-CV diseases, emphasizing its potential in early diagnosis and prognosis. We observed a strong association between CACS and non-CV diseases, viz., chronic obstructive pulmonary disease, pulmonary embolism, pneumonia, diabetes, chronic kidney disease, osteoporosis, metabolic dysfunction-associated steatotic liver disease, nephrolithiasis, stroke, dementia, malignancies, and several autoimmune diseases. Also, CAC may aid in evaluating the risk of CV conditions developing secondary to the non-CV diseases mentioned earlier. Further evidence from prospective studies, intervention trials, and population-based behavioral studies is needed to establish CAC cutoff values and explore preventative care applications, facilitating their broader integration into healthcare practices.
Cortiana et al. (Tue,) conducted a review in Non-cardiovascular diseases. Coronary artery calcium scoring (CACS) was evaluated on Non-cardiovascular diseases and all-cause mortality. Coronary artery calcium scoring is strongly associated with an increased risk of non-cardiovascular diseases and all-cause mortality, highlighting its potential in early diagnosis and prognosis.