Key result
CAC scoring is strongly linked to increased non-cardiovascular disease and all-cause mortality.
Why the study?
Higher coronary artery calcium scores have been linked to increased risk of non-cardiovascular diseases and all-cause mortality, warranting consolidation of evidence on its role in assessing non-cardiovascular disease risk.
Does coronary artery calcium scoring predict the risk of non-cardiovascular diseases and all-cause mortality in asymptomatic individuals?
Does coronary artery calcium scoring predict the risk of non-cardiovascular diseases and all-cause mortality in asymptomatic individuals?
Coronary artery calcium scoring, traditionally used for cardiovascular risk stratification, also demonstrates a strong predictive association with a wide range of non-cardiovascular diseases and all-cause mortality.
Hypothesis-generating for CAC in non-CV risk prediction; leaves open prospective validation before clinical adoption.
Coronary artery calcium scoring (CACS), a non-invasive measure of coronary atherosclerosis, has significantly enhanced cardiovascular (CV) risk assessment and stratification in asymptomatic individuals. More recently, a higher score for CAC has been associated with an increased risk of non-CV diseases and all-cause mortality. This review consolidated evidence supporting the role of CAC in assessing non-CV diseases, emphasizing its potential in early diagnosis and prognosis. We observed a strong association between CACS and non-CV diseases, viz., chronic obstructive pulmonary disease, pulmonary embolism, pneumonia, diabetes, chronic kidney disease, osteoporosis, metabolic dysfunction-associated steatotic liver disease, nephrolithiasis, stroke, dementia, malignancies, and several autoimmune diseases. Also, CAC may aid in evaluating the risk of CV conditions developing secondary to the non-CV diseases mentioned earlier. Further evidence from prospective studies, intervention trials, and population-based behavioral studies is needed to establish CAC cutoff values and explore preventative care applications, facilitating their broader integration into healthcare practices.
No takes yet. Share an insight, caveat, or question.
Cortiana et al. (2024) conducted a review in Non-cardiovascular diseases. Coronary artery calcium scoring (CACS) was evaluated on Non-cardiovascular diseases and all-cause mortality. Coronary artery calcium scoring is strongly associated with an increased risk of non-cardiovascular diseases and all-cause mortality, highlighting its potential in early diagnosis and prognosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: