Adiponectin Protects Against Angiotensin II–Induced Cardiac Fibrosis Through Activation of PPAR-α

Wild-type (WT), adiponectin knockout (Adipo-KO), and PPAR-α knockout (PPAR-α-KO) mice infused with Angiotensin II (Ang II) at 1.2 mg/kg/d; cultured cardiac fibroblasts

Adenovirus-mediated adiponectin treatment

Untreated mice (WT, Adipo-KO, PPAR-α-KO) infused with Ang II

Cardiac fibrosis and left ventricular dysfunctionsurrogate