What question did this study set out to answer?

To determine differences in physical fitness and cardiovascular risk profiles across novel diabetes subgroups compared to a glucose-tolerant control group.

November 8, 2021The Journal of Clinical Endocrinology & MetabolismOpen Access

Physical Fitness and Cardiovascular Risk Factors in Novel Diabetes Subgroups

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Authors

NSNina SaatmannDeutsches Diabetes-Zentrum e.V.OZOana‐Patricia ZahariaDüsseldorf University Hospital KSKlaus StraßburgerDeutsches Diabetes-Zentrum e.V.

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Implication

Prospective cohort study reveals lower physical fitness in severe insulin-resistant diabetes, indicating divergent early cardiovascular risk profiles across newly defined diabetes subgroups.

Key Points

To determine differences in physical fitness and cardiovascular risk profiles across novel diabetes subgroups compared to a glucose-tolerant control group.
Analyzed N=746 participants with recent-onset diabetes (<12 months duration, aged 18–69 years) and N=74 glucose-tolerant controls from the German Diabetes Study, a prospective longitudinal cohort study.
Measured physical fitness using spiroergometry (VO2max), endothelial function via flow- and nitroglycerin-mediated dilation, and cardiovascular risk using Framingham Risk Scores for Coronary Heart Disease (FRS-CHD) and ASCVD risk scores.
VO2max was significantly lower in severe insulin-resistant diabetes (SIRD) compared to controls (P < .001), severe autoimmune diabetes (SAID; P < .001), and mild age-related diabetes (MARD; P < .01), but not different compared to severe insulin-deficient diabetes (SIDD; P = .98) or moderate obesity-related diabetes (MOD; P = .07) after adjusting for age, sex, and BMI.
Endothelial function was similar among all groups, whereas SAID had significantly lower FRS-CHD and ASCVD risk scores compared to SIRD, MOD, and MARD (all P < .001).

Cite This Study

Saatmann et al. (2021) studied this question.

synapsesocial.com/papers/6a0fe5228090e499da6050dd https://doi.org/10.1210/clinem/dgab810

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Implication

Prospective cohort study reveals lower physical fitness in severe insulin-resistant diabetes, indicating divergent early cardiovascular risk profiles across newly defined diabetes subgroups.

Physical Fitness and Cardiovascular Risk Factors in Novel Diabetes Subgroups

Discussion

Member takes

Implication

Key Points

Cite This Study

Physical Fitness and Cardiovascular Risk Factors in Novel Diabetes Subgroups

Discussion

Member takes

Implication

Key Points

Cite This Study

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