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March 26, 2010Journal of Cardiovascular Electrophysiology

Area Under the Real‐Time Contact Force Curve (Force–Time Integral) Predicts Radiofrequency Lesion Size in an In Vitro Contractile Model

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Why the study?

Does contact force-time integral (FTI) predict radiofrequency lesion size in an in vitro contractile model?

Population

In vitro contractile bench model simulating the beating heart using bovine skeletal muscle

Comparison

Radiofrequency energy delivery with variable… vs Constant contact at 20 g

Design

Preclinical

Key result

In an in vitro contractile model, the contact force-time integral correlated linearly with radiofrequency lesion volume (P<0.0001 for 20 and 40 W).

Authors

DSDipen ShahHLHendrik LambertHNHiroshi Nakagawa

Discussion

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Member takes

Overview

Supports FTI for lesion prediction in models; leaves open clinical validation before guiding ablation.

Structured PICO

Does contact force-time integral (FTI) predict radiofrequency lesion size in an in vitro contractile model?

P
Population
In vitro contractile bench model simulating the beating heart using bovine skeletal muscle
I
Intervention
Radiofrequency (RF) energy delivery (20 and 40 W for 60 seconds, 17 cc/min irrigation) with variable contact (20 g peak, 10 g nadir) and intermittent contact (20 g peak, 0 g nadir with loss of contact) at 50 and 100 movements/min
C
Comparator
Constant contact at 20 g
O
Outcome
Lesion volume and its correlation with contact force-time integral (FTI)surrogate

Main Result

p-value: p=<0.0001

In an in vitro contractile model, radiofrequency lesion size correlates linearly with the contact force-time integral, demonstrating that constant contact produces larger lesions than intermittent contact despite identical peak forces.

Cite This Study

Shah et al. (2010) studied Radiofrequency ablation (in vitro model). Radiofrequency energy delivery with variable contact force vs. Constant contact vs variable vs intermittent contact was evaluated on Lesion volume and its correlation with contact force-time integral (FTI) (p=<0.0001). In an in vitro contractile model, the contact force-time integral correlated linearly with radiofrequency lesion volume (P<0.0001 for 20 and 40 W).

synapsesocial.com/papers/6a0fe689fa36b6e053fd0245https://doi.org/10.1111/j.1540-8167.2010.01750.x
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