Narrative review reveals heterogeneous iron distribution and storage dynamics in the human central nervous system, highlighting its role in development, aging, and cognitive attention deficits.
The location and function of iron in the central nervous system are reviewed with particular emphasis on human biology. Iron is distributed to different cell types in the brain in a heterogeneous fashion through the action of transferrin, transferrin receptors, and the metabolic needs of those cells. The function of this iron and its storage is documented in states of growth and development as well as during pathological states associated with aging. The information relating this biology to current observations of attention deficits in iron-deficient humans is also reviewed.
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Beard et al. (2009) studied this question.
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