Key result
End-systolic and stress-shortening relations are reviewed as noninvasive, load-independent measures of intrinsic myocardial contractility, particularly for evaluating dilated cardiomyopathy.
Noninvasive end-systolic and stress-shortening relations may provide a more accurate estimation of intrinsic myocardial contractility in dilated cardiomyopathy than traditional load-dependent indices.
May improve noninvasive contractility assessment in dilated cardiomyopathy; leaves open prospective validation before routine adoption.
Left ventricular performance is usually quantified by ejection phase indices such as ejection fraction, cardiac output, and fractional shortening. The load-dependence of these measures may result in inaccurate estimation of intrinsic myocardial contractility in states of chronic pressure or volume overload. End-systolic and stress-shortening relations have been proposed as measures of contractile state insofar as they are theoretically independent of preload and incorporate afterload. This article examines the behavior of these relations in response to changes in loading conditions and contractile state and reviews their application utilizing noninvasive methodology, particularly in the setting of dilated cardiomyopathy.
No takes yet. Share an insight, caveat, or question.
Roman et al. (1991) conducted a review in Dilated cardiomyopathy. End-systolic and stress-shortening relations vs. Ejection phase indices was evaluated. End-systolic and stress-shortening relations are reviewed as noninvasive, load-independent measures of intrinsic myocardial contractility, particularly for evaluating dilated cardiomyopathy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: