Key result
Adult socioeconomic position and lifestyle accounted for 3.4% of variance in carotid intima-media thickness in men and 7.6% in women, compared to 2.2% and 2.0% for early life variables.
Why the study?
What are the relative contributions of fetal, childhood, and adult life factors to the risk of cardiovascular disease measured by carotid intima-media thickness at age 49-51?
Population
347 adults from the 'Newcastle thousand families' birth cohort established in 1947, assessed at age 49-51…
Design
Cohort
Follow-up
49-51 years
Authors
Loading...
Supports prioritizing adult factors in midlife IMT assessment; hypothesis-generating for life-course CVD prevention strategies.
Cohort (n=347)
What are the relative contributions of fetal, childhood, and adult life factors to the risk of cardiovascular disease measured by carotid intima-media thickness at age 49-51?
Adult lifestyle and biological risk markers are more important determinants of cardiovascular health (measured by carotid IMT) at age 49-51 than early life factors in this cohort.
D. Lamont (2000) conducted a cohort in Cardiovascular disease risk (n=347). Lifecourse factors (fetal, childhood, and adult life) was evaluated on Proportions of variance in carotid intima-media thickness accounted for by each stage of the lifecourse. Adult socioeconomic position and lifestyle accounted for 3.4% of variance in carotid intima-media thickness in men and 7.6% in women, compared to 2.2% and 2.0% for early life variables.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: