Why the study?
Are high lipoprotein and triglyceride levels associated with increased all-cause mortality in subjects aged 50+ without previous diabetes or cardiovascular disease?
Population
118,160 subjects aged 50+ without previous diabetes or cardiovascular disease, and without statin use at…
Comparison
Total cholesterol ≥ 5 mmol/L or LDL-C ≥ 3 mmol/L… vs Total cholesterol < 5 mmol/L, LDL-C < 3 mmol/L…
Design
Cohort
Follow-up
1999-2007
Authors
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May not support lowering TC/LDL-C targets for primary prevention in adults ≥50 without CVD; leaves open causal effects on mortality.
Are high lipoprotein and triglyceride levels associated with increased all-cause mortality in subjects aged 50+ without previous diabetes or cardiovascular disease?
High lipoprotein levels are not associated with increased all-cause mortality in a general population aged 50+ without diabetes or CVD, challenging current guideline targets for primary prevention in this group.
Bathum et al. (2013) studied this question.
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