March 31, 2025Frontiers in Clinical Diabetes and HealthcareOpen Access

Effect of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, on ventricular repolarization electrocardiographic parameters in type 2 diabetes patients: DAPA - ECG study

Q: What are the key findings of this study?

Dapagliflozin significantly reduced the TpTe interval from 76.87 ms to 67.8 ms compared to GDMT alone over three months in patients with type 2 diabetes.

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Type 2 diabetes mellitus (n=174). Intervention: Dapagliflozin vs. Guideline directed medical therapy (GDMT) alone. Primary outcome: Change in the duration of the TpTe interval (Cohen's d 0.746, p=<0.001).

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Key result

Dapagliflozin shortens the TpTe interval by ~9 ms vs GDMT alone in type 2 diabetes.

Cohen's d 0.746
P<0.001
n=174

Why the study?

The exact mechanisms underlying the cardiovascular benefits of dapagliflozin in patients with type 2 diabetes are not fully understood.

Does dapagliflozin improve ventricular repolarization electrocardiographic parameters in adult patients with type 2 diabetes?

Population

174 patients with T2DM

Comparison

Dapagliflozin plus optimized GDMT vs optimized GDMT without SGLT2 inhibitors

Design

Randomized, multicenter, prospective study

Authors

RCRodrigo Noronha Campos DMDalmo Antônio Ribeiro Moreira GFGabriel M. Fonseca

Discussion

Member takes

Overview

May reduce arrhythmia risk via repolarization in T2D; extends weak low-certainty RCT evidence.

Study Design

Type

RCT (n=174)

Blinding

Open-label

Randomization

1:1

Multicenter

Yes

Structured PICO

Does dapagliflozin improve ventricular repolarization electrocardiographic parameters in adult patients with type 2 diabetes?

Population

174 adult patients (≥18 years) with type 2 diabetes (T2DM), BMI ≤45, and glomerular filtration rate (GFR) ≥30 ml/min/1.73 m². Exclusions included QRS interval >120 ms, use of insulin or weight-loss medication in the prior 3 months, pregnancy/breastfeeding, atrial fibrillation, pacemaker or cardiac resynchronization therapy (CRT), uncontrolled blood glucose (>240 mg/dL fasting), significant liver disease, or planned cardiac surgery/angioplasty.

Intervention

Dapagliflozin 10 mg once daily combined with optimized guideline-directed medical therapy (GDMT) for 3 months.

Comparator

Optimized guideline-directed medical therapy (GDMT) alone (excluding SGLT2 inhibitors) for 3 months.

Outcome

Change in the duration of the TpTe interval (time between the peak and the end of the T wave) measured in lead V5 at 3 months.surrogate

Main Result

Effect estimate: Cohen's d 0.746

Absolute Event Rate: 67.8% vs 73.76%

p-value: p=<0.001

Dapagliflozin significantly shortened the TpTe and QTc intervals in patients with type 2 diabetes, suggesting a reduction in ventricular electrical remodeling and a potential cardioprotective antiarrhythmic effect.

Limitations

Application of specific inclusion and exclusion criteria restricted the generalizability of the findings
Open design of the study and the lack of blinding
Specific inclusion and exclusion criteria restricted generalizability
Open design
Lack of blinding

Cite This Study

Campos et al. (2025) conducted an RCT in Type 2 diabetes mellitus (n=174). Dapagliflozin vs. Guideline directed medical therapy (GDMT) alone was evaluated on Change in the duration of the TpTe interval (Cohen's d 0.746, p=<0.001). Dapagliflozin significantly reduced the TpTe interval from 76.87 ms to 67.8 ms compared to GDMT alone over three months in patients with type 2 diabetes.

synapsesocial.com/papers/6a0fed08b6f5ee0401601a10 https://doi.org/10.3389/fcdhc.2025.1537005

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March 31, 2025Frontiers in Clinical Diabetes and HealthcareOpen Access

Effect of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, on ventricular repolarization electrocardiographic parameters in type 2 diabetes patients: DAPA - ECG study

View Full Paper

Ask AI

Bookmark

Key result

Dapagliflozin shortens the TpTe interval by ~9 ms vs GDMT alone in type 2 diabetes.

Cohen's d 0.746
P<0.001
n=174

Why the study?

The exact mechanisms underlying the cardiovascular benefits of dapagliflozin in patients with type 2 diabetes are not fully understood.

Does dapagliflozin improve ventricular repolarization electrocardiographic parameters in adult patients with type 2 diabetes?

Population

174 patients with T2DM

Comparison

Dapagliflozin plus optimized GDMT vs optimized GDMT without SGLT2 inhibitors

Design

Randomized, multicenter, prospective study

Authors

RCRodrigo Noronha Campos DMDalmo Antônio Ribeiro Moreira GFGabriel M. Fonseca

Discussion

Member takes

Overview

May reduce arrhythmia risk via repolarization in T2D; extends weak low-certainty RCT evidence.

Study Design

Type

RCT (n=174)

Blinding

Open-label

Randomization

1:1

Multicenter

Yes

Structured PICO

Does dapagliflozin improve ventricular repolarization electrocardiographic parameters in adult patients with type 2 diabetes?

Population

Intervention

Dapagliflozin 10 mg once daily combined with optimized guideline-directed medical therapy (GDMT) for 3 months.

Comparator

Optimized guideline-directed medical therapy (GDMT) alone (excluding SGLT2 inhibitors) for 3 months.

Outcome

Change in the duration of the TpTe interval (time between the peak and the end of the T wave) measured in lead V5 at 3 months.surrogate

Main Result

Effect estimate: Cohen's d 0.746

Absolute Event Rate: 67.8% vs 73.76%

p-value: p=<0.001

Limitations

Application of specific inclusion and exclusion criteria restricted the generalizability of the findings
Open design of the study and the lack of blinding
Specific inclusion and exclusion criteria restricted generalizability
Open design
Lack of blinding

Cite This Study

synapsesocial.com/papers/6a0fed08b6f5ee0401601a10 https://doi.org/10.3389/fcdhc.2025.1537005

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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