What question did this study set out to answer?

To determine whether ascorbate uniquely shields human blood plasma lipids from peroxidative damage caused by aqueous peroxyl radicals.

August 1, 1989Proceedings of the National Academy of SciencesOpen Access

Ascorbate is an outstanding antioxidant in human blood plasma.

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To determine whether ascorbate uniquely shields human blood plasma lipids from peroxidative damage caused by aqueous peroxyl radicals.
Exposed human blood plasma samples in vitro to a continuous flux of aqueous peroxyl radicals.
Monitored the sequential depletion of endogenous antioxidants including ascorbate, protein thiols, bilirubin, urate, and alpha-tocopherol alongside the onset of lipid peroxidation.
Evaluated susceptibility to peroxidative lipid damage in plasma selectively depleted of ascorbate compared to plasma depleted of other endogenous antioxidants.
Ascorbate completely prevented detectable lipid peroxidation until it was entirely consumed, acting as the only endogenous plasma antioxidant capable of providing complete protection.
Protein thiols oxidized immediately upon exposure to aqueous peroxyl radicals but acted as inefficient scavengers that were consumed primarily through autoxidation.
Plasma selectively lacking ascorbate showed extreme vulnerability to oxidant stress and lipid peroxidation, whereas the absence of other endogenous antioxidants did not trigger lipid damage.

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Implication

Experimental study demonstrates ascorbate completely prevents aqueous radical-induced lipid peroxidation in human blood plasma, indicating its vital role against oxidant-driven degenerative diseases.

Cite This Study

Frei et al. (1989) studied this question.

synapsesocial.com/papers/6a0fef6f92676d5461fd499c https://doi.org/10.1073/pnas.86.16.6377

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Implication

Experimental study demonstrates ascorbate completely prevents aqueous radical-induced lipid peroxidation in human blood plasma, indicating its vital role against oxidant-driven degenerative diseases.

Ascorbate is an outstanding antioxidant in human blood plasma.

Key Points

Discussion

Implication

Cite This Study

Ascorbate is an outstanding antioxidant in human blood plasma.

Key Points

Discussion

Implication

Cite This Study

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