Key result
Active jobs in men (HR 2.7; 95% CI 1.5-4.9) and high-strain jobs in women (HR 2.2; 95% CI 1.0-4.6) significantly increased the risk of incident metabolic syndrome over 5 years.
Why the study?
Does job strain increase the risk of incident metabolic syndrome in young adults?
Cohort (n=2,966)
Does job strain increase the risk of incident metabolic syndrome in young adults?
Effect estimate: HR 2.7 (men) / HR 2.2 (women) (95% CI 1.5-4.9 (men) / 1.0-4.6 (women))
Job strain is associated with an increased risk of developing metabolic syndrome over 5 years, suggesting occupational stress is a modifiable risk factor for cardiovascular disease.
Job strain was associated with metabolic syndrome risk; hypothesis-generating and requires prospective trials before practice change.
BACKGROUND: Theories of stress-induced metabolic syndrome predict that job strain would increase risk. Few studies have evaluated this association. OBJECTIVE: To evaluate the association between job strain and the risk of metabolic syndrome. METHODS: We investigated associations between job strain and incident metabolic syndrome adjusted for sociodemographic factors, health behaviors, and depressive symptoms over 5 years among 2966 black and white men and women in the Coronary Artery Risk Development in Young Adults study. Job strain was categorized by Karasek's model: high demands/low control; high demands/high control; low demands/low control; and low demands/high control. RESULTS: Compared with persons in low-strain jobs, men in active jobs (adjusted hazards ratio, 2.7; 95% confidence interval, 1.5 to 4.9) and women in high strain jobs (adjusted hazards ratio, 2.2; 95% confidence interval, 1.0 to 4.6) had significantly increased risk of metabolic syndrome. CONCLUSION: Job strain may be a modifiable risk factor for metabolic syndrome and subsequent cardiovascular disease.
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Edwards et al. (2012) conducted a cohort in Metabolic syndrome (n=2,966). Job strain vs. Low-strain jobs was evaluated on Incident metabolic syndrome (HR 2.7 (men) / HR 2.2 (women), 95% CI 1.5-4.9 (men) / 1.0-4.6 (women)). Active jobs in men (HR 2.7; 95% CI 1.5-4.9) and high-strain jobs in women (HR 2.2; 95% CI 1.0-4.6) significantly increased the risk of incident metabolic syndrome over 5 years.