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May 1, 2026International Journal of Biological SciencesOpen Access

CRL4 AMBRA1 -mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer

Yaru Sheng Ting Ni Xiaoyi Ding Jiaying Huang Xueya Zhao Xinyao Li Qingting Li Jing Wang Xiaoming Yang Lin Zhang Xuan Zheng Dan Cao Rongjia Su Xiaojing Lu Jin Hou Yudong Wang

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Key Points

The research investigates how CRL4 AMBRA1-mediated degradation of the progesterone receptor contributes to progestin resistance in endometrial cancer.
Analyzed the role of CRL4 AMBRA1 in progesterone receptor degradation.
Examined progestin resistance mechanisms in endometrial cancer models.
Demonstrated that CRL4 AMBRA1-mediated degradation leads to increased progestin resistance.
Identified CRL4 AMBRA1 as a potential therapeutic target for treating endometrial cancer.

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Implication

Reveals CRL4 AMBRA1's role in progestin resistance in endometrial cancer, suggesting a potential treatment target.

Abstract

complex as a potential therapeutic target for overcoming MPA resistance in EC.

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Cite This Study

Sheng et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff1dbd674f7c03778b001 https://doi.org/10.7150/ijbs.133072

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