What question did this study set out to answer?

To assess the humoral and cellular immune responses to SARS-CoV-2 vaccination in patients with immune-mediated diseases on immunosuppressive therapy.

May 22, 2026Frontiers in ImmunologyOpen Access

Humoral and cell mediated immune response to SARS-CoV-2 vaccination in patients with immune-mediated diseases

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Authors

DGDorey A. GlennUniversity of North Carolina at Chapel Hill YHYichun HuUniversity of North Carolina at Chapel Hill MFMeghan E. FreeUniversity of North Carolina at Chapel Hill

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Implication

Observational cohort study investigates immune responses to SARS-CoV-2 vaccination in immune-mediated disease patients, indicating implications for vaccination strategies.

Key Points

To assess the humoral and cellular immune responses to SARS-CoV-2 vaccination in patients with immune-mediated diseases on immunosuppressive therapy.
Conducted a single-center prospective observational cohort study with 80 patients and 12 healthy controls.
Assessed antibody response through viral neutralization and cellular immunity at various time points post-vaccination.
Followed participants for a median of 11.97 months, collecting samples for analysis.
Median ACE2 neutralization was 46.9% in patients with immune-mediated diseases versus 95.9% in healthy controls (p<0.001).
Only 11.9% of patients receiving anti-CD20 therapy had protective neutralization titers at V1.
T-ELISpot counts (RBD) were comparable between both groups, indicating preserved T cell responses despite impaired humoral immunity.

Cite This Study

Glenn et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff1dbd674f7c03778b0a2 https://doi.org/10.3389/fimmu.2026.1813924

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Implication

Observational cohort study investigates immune responses to SARS-CoV-2 vaccination in immune-mediated disease patients, indicating implications for vaccination strategies.

Humoral and cell mediated immune response to SARS-CoV-2 vaccination in patients with immune-mediated diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Humoral and cell mediated immune response to SARS-CoV-2 vaccination in patients with immune-mediated diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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