Effectiveness of ozonized oil-based ear drops in patients with external ear canal dermatitis: a prospective observational study

Introduction Dermatitis of the external ear canal is an inflammatory condition characterized by itching, desquamation, erythema, and discomfort. Although topical corticosteroids are commonly used as first-line therapy, prolonged administration may lead to adverse effects, including skin atrophy and irritation. Therefore, alternative treatments with a safer profile are being explored. Ozonized oil has gained attention due to its antimicrobial, anti-inflammatory, and tissue-repairing properties. This study aimed to evaluate the effectiveness and safety of ozonized oil-based ear drops in reducing symptoms and improving clinical signs in patients with non-infectious dermatitis of the external ear canal. Materials and Methods In this prospective observational study, adult patients diagnosed with non-infectious dermatitis of the external ear canal were enrolled. Participants were treated with ozonized oil-based ear drops twice daily for 2 weeks. Clinical effectiveness was assessed before and after treatment using the Modified Itch Severity Scale (MISS), the Visual Analog Scale (VAS) for pain, and otoscopic evaluation of hyperemia, edema, and desquamation. Statistical analysis was performed using the Wilcoxon signed-rank test. Results Thirty-five patients were enrolled, and 33 completed the study. Treatment resulted in a significant reduction in itching frequency and intensity (p < 0.001), as well as improvement in otoscopic signs (p < 0.001). Sleep onset improved significantly, while nighttime awakenings did not. Mild otalgia occurred in three patients and resolved. No adverse effects were reported. Conclusion Ozonized oil-based ear drops were associated with an improvement in symptoms and otoscopic findings in this prospective observational study. However, controlled studies are required to confirm these findings.