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This review examines how maternal malnutrition affects placental programming and offspring health, emphasizing long-term implications.

Placental Programming in Maternal Malnutrition as a Crucial Determinant of Offspring Health: A Critical-Interpretative Narrative Review

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Critical-interpretative narrative review highlights how maternal nutrition impacts fetal health, indicating vital pathways.

This review examines how maternal malnutrition affects placental programming and offspring health, emphasizing long-term implications.
Critical-interpretative narrative review of existing literature
Focus on maternal nutritional disorders such as protein restriction, micronutrient deficiencies, and high-fat diets
Discussion of sex-specific placental responses and pathophysiological mechanisms
Maternal nutritional disorders alter placental efficiency, impacting fetal development and increasing NCD susceptibility.
Sex-specific responses show adaptive changes in placentas of females versus adverse effects in males.
Identified potential molecular and biochemical mechanisms for placental dysregulation related to maternal health.

Barata et al. (2026) studied this question.

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