Key result
Adolescent major depressive disorder is linked to later sleep onset and lower sleep regularity.
Why the study?
Rest-activity rhythm disruptions are implicated in adults with MDD, but their roles in adolescent MDD and subclinical depressive presentations remain unclear.
Are rest-activity rhythm disruptions associated with clinical and subclinical depression in adolescents?
Population
148 Chinese adolescents aged 12-18
Comparison
MDD vs subthreshold depression vs healthy controls
Design
Observational cross-sectional study
Follow-up
14-day actigraphy assessment
Authors
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May support RAR monitoring in adolescent depression assessment; extends adult data to youth but leaves open causal and interventional implications.
Observational (n=148)
Are rest-activity rhythm disruptions associated with clinical and subclinical depression in adolescents?
p-value: p=<0.001
Adolescent depression is associated with disrupted rest-activity rhythms, with later sleep onset in both clinical and subclinical depression and pronounced sleep irregularity in clinical depression.
Cho et al. (2026) conducted an observational in Major depressive disorder and subthreshold depression (n=148). 14-day actigraphy assessment vs. Healthy controls was evaluated on Sleep onset and sleep regularity index (p=<0.001). Adolescents with major depressive disorder exhibited significantly later sleep onset (p=0.020) and lower sleep regularity (p<0.001) compared to healthy controls.
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