What question did this study set out to answer?

This study aims to characterize how nutritional restriction during late gestation affects placental transcriptional programs related to metabolism and immune function.

May 22, 2026BMC GenomicsOpen Access

Nutritional restriction during late gestation disrupts placental transcriptional programs related to metabolism, transport, and immune function in a sheep model

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Authors

WWWeibin WuAnhui Agricultural University YXYe XuZhejiang Chinese Medical University PLPengpeng LiuBiotechnology Institute

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Implication

Randomized trial examines nutritional impact on placental function in late-gestation ewes, suggesting implications for fetal development.

Key Points

This study aims to characterize how nutritional restriction during late gestation affects placental transcriptional programs related to metabolism and immune function.
Late-gestation ewes were subject to 30% feeding levels for 15 days to induce undernutrition.
Placental weight and cotyledon number were measured to assess placental efficiency.
Transcriptional changes in metabolism, transport, and immune pathways were analyzed in response to nutritional restriction.
Nutritional restriction did not affect placental weight or cotyledon number but reduced placental efficiency.
Carbohydrate metabolism decreased, while glucose and essential amino acid levels increased in umbilical cord blood.
Immunological pathways were inhibited, indicating compromised immune function in the placenta.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff2f5d674f7c03778b592 https://doi.org/10.1186/s12864-026-12973-8

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Nutritional restriction during late gestation disrupts placental transcriptional programs related to metabolism, transport, and immune function in a sheep model

Discussion

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Implication

Key Points

Cite This Study

Nutritional restriction during late gestation disrupts placental transcriptional programs related to metabolism, transport, and immune function in a sheep model

Discussion

Member takes

Implication

Key Points

Cite This Study

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