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May 22, 2026BMC MicrobiologyOpen Access

Synergistic antimicrobial and antibiofilm effects of mycosynthesized MnO–MgO bimetallic nanoparticles against drug-resistant pathogens

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Randomized trial demonstrates antimicrobial effects in drug-resistant pathogens, suggesting a novel treatment approach.

This research aims to evaluate the synergistic antimicrobial and antibiofilm effects of mycosynthesized MnO-MgO nanoparticles against drug-resistant bacteria.
MnO-MgO BNPs were synthesized using Aspergillus niger extract.
Characterization included UV-vis, FTIR, EDX, TEM/SEM, and XRD analyses.
Biological evaluation involved measuring antimicrobial activity and cytotoxicity in a quantitative analysis.
Broad-spectrum antibacterial activity was observed with a 25.67 mm inhibition zone against Escherichia coli.
MIC values ranged from 32 to 256 µg/mL; the lowest MIC₅₀ recorded was 11.56 µg/mL for Staphylococcus saprophyticus.
Antibiofilm effectiveness reached 92.04% inhibition in Proteus mirabilis, showing high synergistic interaction with amoxicillin (FICI of 0.375).

Elkady et al. (2026) studied this question.

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