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May 22, 2026npj Precision OncologyOpen Access

Decoding the crosstalk between ubiquitination and other post-translational modifications in cancer immunity: from mechanisms to clinical prospects

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Authors

KLKai-Qiang LiSDSi-Qi DingYLYun Lei

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Overview

Review discusses mechanisms linking ubiquitination and other modifications to cancer immunity, suggesting therapeutic strategies.

Key Points

  • This review aims to explore the interactions between ubiquitination and other post-translational modifications in the context of cancer immunity.
  • Reviewed existing literature on post-translational modifications in cancer immunology.
  • Discussed regulatory mechanisms impacting immune checkpoint proteins and immune cell functionality.
  • Summarized potential therapeutic approaches targeting these modifications.
  • Ubiquitination and other PTMs like phosphorylation affect PD-L1 stability and immune response.
  • PTMs modulate immune cell functions and key signaling pathways crucial for tumor microenvironment.
  • Therapeutic strategies such as small-molecule inhibitors and PROTACs may enhance immunotherapy effectiveness.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff2f5d674f7c03778b699https://doi.org/10.1038/s41698-026-01488-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ubiquitin-centered post-translational modification crosstalk orchestrates tumor immunity and immunotherapy response.2026 · 3 citations
  2. 2Post-translational modifications of immune checkpoints: unlocking new potentials in cancer immunotherapy2025 · 20 citations
  3. 3Immunoregulatory roles of post-translational modifications in colorectal cancer: mechanisms and therapeutic implications2025
  4. 4Post‐Translational Regulation of CD8 <sup>+</sup> T Cell Fate and Dysfunction in Tumor Immunity2026 · 1 citations
  5. 5Post‑translational modification‑governed immune states in cancer immunity: Biomarker implications for checkpoint competence, tumor visibility and immunotherapy resistance (Review)2026