What is the clinical evidence from this study?

Study design: Cohort. Population: Cardiometabolic multimorbidity (n=11365). Intervention: Oxidative balance score (OBS) vs. Lower OBS. Primary outcome: All-cause mortality (HR 0.85).

What does this research mean for the field?

Each 5-point increase in the oxidative balance score is associated with lower odds of cardiometabolic multimorbidity (OR 0.96) and reduced risks of all-cause mortality (HR 0.85), with effects partially mediated by inflammatory and insulin resistance pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the association between oxidative balance score and cardiometabolic multimorbidity, along with its impact on mortality.

May 22, 2026Journal of Translational MedicineOpen Access

Each 5-point oxidative balance score increase is associated with ~15% lower mortality and less cardiometabolic multimorbidity.

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Why the study?

The oxidative balance score had not been systematically evaluated in relation to cardiometabolic multimorbidity and mortality.

Is a higher oxidative balance score associated with reduced cardiometabolic multimorbidity and mortality in NHANES participants?

Population

11,365 NHANES participants

Comparison

Associations across different levels of oxidative balance score

Design

Observational analysis using logistic regression, Cox models, and machine learning

Key result

Each 5-point increase in the oxidative balance score was associated with lower odds of cardiometabolic multimorbidity (OR 0.96) and reduced risks of all-cause mortality (HR 0.85).

Authors

STSiyuan Tan GZGaoming Zeng THTing Huang

Discussion

Member takes

Overview

Higher OBS may support CMM risk reduction efforts; leaves open causality and interventional benefits in cardiometabolic populations.

Key Points

To evaluate the association between oxidative balance score and cardiometabolic multimorbidity, along with its impact on mortality.
Analyzed 11,365 NHANES participants for associations between oxidative balance score and cardiometabolic multimorbidity.
Utilized logistic regression and Cox proportional hazards models for outcome assessment.
Applied machine learning techniques to identify key predictors associated with health outcomes.
Participants with higher oxidative balance scores had lower odds of cardiometabolic multimorbidity (OR = 0.96).
Each 5-point increase in oxidative balance score corresponded to reduced all-cause mortality risk (HR = 0.85).
Machine learning found body mass index, physical activity, and vitamin intake as important predictors for cardiometabolic outcomes.

Study Design

Type

Cohort (n=11,365)

Structured PICO

Is a higher oxidative balance score associated with reduced cardiometabolic multimorbidity and mortality in NHANES participants?

Population

11,365 NHANES participants, median age 45 years, 52.55% male

Intervention

Higher oxidative balance score (OBS)

Comparator

Lower oxidative balance score (OBS)

Outcome

Cardiometabolic multimorbidity (CMM) and all-cause mortalityhard clinical

Main Result

Effect estimate: HR 0.85

Higher oxidative balance score is associated with lower cardiometabolic multimorbidity prevalence and reduced mortality risk, partially mediated by inflammatory and insulin resistance pathways.

Cite This Study

Tan et al. (2026) conducted a cohort in Cardiometabolic multimorbidity (n=11,365). Oxidative balance score (OBS) vs. Lower OBS was evaluated on All-cause mortality (HR 0.85). Each 5-point increase in the oxidative balance score was associated with lower odds of cardiometabolic multimorbidity (OR 0.96) and reduced risks of all-cause mortality (HR 0.85).

synapsesocial.com/papers/6a0ff327d674f7c03778ba03 https://doi.org/10.1186/s12967-026-08291-y

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May 22, 2026Journal of Translational MedicineOpen Access

Each 5-point oxidative balance score increase is associated with ~15% lower mortality and less cardiometabolic multimorbidity.

View Full Paper

Ask AI

Bookmark

Why the study?

The oxidative balance score had not been systematically evaluated in relation to cardiometabolic multimorbidity and mortality.

Is a higher oxidative balance score associated with reduced cardiometabolic multimorbidity and mortality in NHANES participants?

Population

11,365 NHANES participants

Comparison

Associations across different levels of oxidative balance score

Design

Observational analysis using logistic regression, Cox models, and machine learning

Key result

Each 5-point increase in the oxidative balance score was associated with lower odds of cardiometabolic multimorbidity (OR 0.96) and reduced risks of all-cause mortality (HR 0.85).

Authors

STSiyuan Tan GZGaoming Zeng THTing Huang

Discussion

Member takes

Overview

Higher OBS may support CMM risk reduction efforts; leaves open causality and interventional benefits in cardiometabolic populations.

Key Points

To evaluate the association between oxidative balance score and cardiometabolic multimorbidity, along with its impact on mortality.
Analyzed 11,365 NHANES participants for associations between oxidative balance score and cardiometabolic multimorbidity.
Utilized logistic regression and Cox proportional hazards models for outcome assessment.
Applied machine learning techniques to identify key predictors associated with health outcomes.
Participants with higher oxidative balance scores had lower odds of cardiometabolic multimorbidity (OR = 0.96).
Each 5-point increase in oxidative balance score corresponded to reduced all-cause mortality risk (HR = 0.85).
Machine learning found body mass index, physical activity, and vitamin intake as important predictors for cardiometabolic outcomes.

Study Design

Type

Cohort (n=11,365)

Structured PICO

Is a higher oxidative balance score associated with reduced cardiometabolic multimorbidity and mortality in NHANES participants?

Population

11,365 NHANES participants, median age 45 years, 52.55% male

Intervention

Higher oxidative balance score (OBS)

Comparator

Lower oxidative balance score (OBS)

Outcome

Cardiometabolic multimorbidity (CMM) and all-cause mortalityhard clinical

Main Result

Effect estimate: HR 0.85

Higher oxidative balance score is associated with lower cardiometabolic multimorbidity prevalence and reduced mortality risk, partially mediated by inflammatory and insulin resistance pathways.

Cite This Study

synapsesocial.com/papers/6a0ff327d674f7c03778ba03 https://doi.org/10.1186/s12967-026-08291-y

View Full Paper

Ask AI

Bookmark