Interpretation of Potential Interactions and Adverse Effects by Apigenin and Chrysin Based on Their Regulation of Metabolizers and Transporters in Mouse Embryonic Fibroblasts

Apigenin and chrysin are chemically close and related flavonoids. Our previous works have demonstrated both apigenin and chrysin's ability to reduce cholesterol and uric acid biosynthesis along with upregulation of ketone bodies and endogenous anti-inflammatory lipids. Current work based on transcriptomics approach has shed light into their ability to influence endogenous metabolites or xenobiotic metabolism by regulating CYP isoforms. This work is based on analyzing raw data for transcriptomics, which we previously performed on mouse embryonic fibroblasts (MEFs). Following transcriptomics, we have added our raw data to NIH - Gene Expression Omnibus (GEO) with Accession Number - GSE155852. We have selected top 5 altered targets which are CYP450 family members and provided our perspective on how apigenin or chrysin administration could influence our metabolic status or drug metabolizing ability. In addition, we have also analyzed the impact of apigenin and chrysin treatment on glutathione S-transferase and ATP-binding cassette family members. This work will really shed light upon metabolizing and drug interaction capabilities of these flavonoids through the regulation of major cellular drug metabolizers and transporters.