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May 22, 2026Dermatologic Surgery

Imiquimod for Melanoma in Situ and Lentigo Maligna: A Systematic Review

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Authors

JFJacob W. FayNortheast Ohio Medical UniversityKKKelly M. KimballOhioHealthNHNicholas W. HartmanNortheast Ohio Medical University

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Overview

Systematic review evaluates imiquimod's effectiveness for melanoma in situ and lentigo maligna, suggesting a viable nonsurgical treatment option.

Key Points

  • This review aims to evaluate the efficacy, safety, and treatment protocols of topical imiquimod for melanoma in situ and lentigo maligna.
  • Conducted a systematic review of literature from multiple databases.
  • Included studies with histologically confirmed melanoma in situ or lentigo maligna treated with imiquimod.
  • Outcomes assessed included histological clearance rates, recurrence rates, and adverse events.
  • Histological clearance rates for imiquimod were approximately 84.5%, with a range of 77% to 90%.
  • Recurrence rates among follow-up cases ranged from 0.5% to 15%.
  • Common adverse effects included erythema and local irritation, linked to treatment success.

Cite This Study

Fay et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff351d674f7c03778bec9https://doi.org/10.1097/dss.0000000000005174
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Imiquimod: mode of action2007 · 348 citations
  2. 2Imiquimod in the treatment of lentigo maligna2006 · 99 citations
  3. 3Treatment of Lentigo Maligna (Melanoma In Situ) With the Immune Response Modifier Imiquimod2005 · 104 citations
  4. 4Imiquimod: a novel treatment for lentigo maligna2000 · 213 citations
  5. 5A Randomized Trial of the Off-label Use of Imiquimod, 5%, Cream With vs Without Tazarotene, 0.1%, Gel for the Treatment of Lentigo Maligna, Followed by Conservative Staged Excisions2012 · 89 citations