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May 22, 2026Health Science ReportsOpen Access

Is Environmental Enteric Dysfunction Reversible in Adults? A 7‐Year Observational Follow‐up Study of Histological and Biomarker Outcomes in Urban Bangladesh

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Authors

ARA. H. M. RezwanAKAr‐Rafi KhanSIShaumik Islam

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Overview

Observational study shows EED reversal associated with improved sanitation and living conditions in adults, suggesting integrated interventions may help.

Key Points

  • To investigate the reversibility of Environmental Enteric Dysfunction (EED) in adults over a 7-year period.
  • Conducted follow-up on 39 adults originally diagnosed with EED from a baseline study in Bangladesh.
  • Assessed anthropometry, hygiene conditions, and stool biomarkers including MPO, NEO, and AAT.
  • Used Fisher's exact test and Firth's logistic regression to analyze associations between environmental changes and EED reversal.
  • 28.2% (11/39) of participants met the criteria for EED reversal after 7 years.
  • Median BMI increased from 17.2 to 18.5 kg/m² with significant declines in NEO and MPO levels.
  • Improved sanitation (uOR: 6.36), reduced overcrowding (uOR: 4.61), and higher social class (uOR: 8.61) were significantly associated with EED reversal.

Cite This Study

Rezwan et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff374d674f7c03778c1efhttps://doi.org/10.1002/hsr2.72549
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  1. 1Elevated Levels of Environmental Enteric Dysfunction Biomarkers Among Rural Indonesian Infants: Associations with Water, Sanitation, Hygiene and Linear Growth2026 · 1 citations
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  3. 3Mapping global research on environmental enteric dysfunction: A bibliometric study of trends and emerging themes2026
  4. 4Sociodemographic factors of Environmental Enteropathy among Egyptian infants and children; A Retrospective Case-Control Study.2026
  5. 5Small intestinal microbiota of undernourished women of reproductive age and microbiota-directed balanced energy protein (MD-BEP) supplementation in maternal environmental enteric dysfunction (EED): protocol for a community-based intervention study2026