PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
May 22, 2026Degenerative Neurological and Neuromuscular DiseaseOpen Access

(Z)-Endoxifen as a Potential Modulator of Utrophin Pathways in Duchenne Muscular Dystrophy: A Mechanistic and Transcriptomic Perspective

View Full Paper
Ask AI
Bookmark
Share

Authors

HRH Lawrence RemmelSHSandra HammerSBScott Blackburn

Discussion

Loading...

Member takes

Overview

Randomized trial evaluates (Z)-endoxifen's effects on muscle regeneration in Duchenne muscular dystrophy, suggesting a new therapeutic approach.

Key Points

  • The study aims to investigate the potential of (Z)-endoxifen as a modulator of utrophin pathways in Duchenne muscular dystrophy.
  • Examined mechanistic effects of (Z)-endoxifen on DMD pathology in preclinical models.
  • Assessed transcriptomic profiles to identify changes in gene expression.
  • Evaluated the impact on multiple dysfunctional pathways associated with DMD.
  • (Z)-endoxifen showed enhanced effects compared to tamoxifen in reversing DMD-associated signatures.
  • Activation of myogenesis and oxidative phosphorylation pathways was demonstrated.
  • Inhibition of pro-inflammatory and epithelial-to-mesenchymal transition pathways supports its therapeutic profile.

Cite This Study

Remmel et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff38cd674f7c03778c466https://doi.org/10.2147/dnnd.s574524
View Full Paper
Ask AI
Bookmark
Share