Narrative review examines spermidine's effects on cognition and neuroprotection in aging populations, suggesting potential benefits.
Key Points
The aim is to explore spermidine's neuroprotective mechanisms and its potential impact on Alzheimer's disease through available evidence.
Conducted a narrative review of preclinical and clinical studies examining spermidine's effects on Alzheimer's disease and cognitive function.
Analyzed mechanisms such as autophagy activation, mitochondrial health, and neuroinflammation mitigation associated with spermidine.
Reviewed observational and randomized clinical trial data for dietary spermidine intake and cognitive outcomes.
Preclinical studies support that spermidine enhances autophagy and cognitive performance in animal models.
Observational studies suggest a positive association between higher dietary spermidine intake and cognitive function, though causality remains unproven.
Current randomized clinical trials show mixed results with small populations, lacking consistent effects on cognitive endpoints.