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Research reveals spermidine's potential role in promoting health during aging, suggesting pathways for clinical trials.
Aging is associated with increased oxidative stress, which leads to pathological vulnerability. Spermidine is a ubiquitous natural polyamine found across all living organisms studied so far and present in multiple food sources. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentration and age-related organ degeneration has been proposed. We outline recent studies that address the potential contribution of spermidine to geroprotection, with a perspective of advancing spermidine towards clinical trials.
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Jiang et al. (2026) studied this question.
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