Soft sensor based on pH for real-time monitoring of mRNA medicines production

Mahdi Ahmed; Shady Hamed; Ricardo Cardoso; Charley Kenyon; Manoj Pohare; Mabrouka Maamra; Mark J Dickman; Joan Cordiner; Zoltan Kis

doi:10.1039/d5dd00417a

January 1, 2026Digital DiscoveryOpen Access

Soft sensor based on pH for real-time monitoring of mRNA medicines production

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Key Points

The aim is to establish a soft sensor for real-time monitoring of in vitro transcription reactions in mRNA production.
Developed a soft sensor based on pH for monitoring IVT reactions.
Evaluated its performance in real-time conditions for mRNA therapeutics production.
Analyzed data to assess the quality of mRNA produced during the IVT process.
Achieved precise tracking of pH changes during IVT reactions, reflecting real-time mRNA synthesis.
Demonstrated that the soft sensor effectively correlates pH levels with mRNA quality metrics.
Highlighted advantages of continuous monitoring compared to traditional batch methods.

Implication

Uncovers the effectiveness of a soft sensor for real-time mRNA production monitoring, indicating its potential for quality control.

Abstract

Real-time monitoring of in vitro transcription (IVT) reactions is critical for the continuous manufacturing of high-quality mRNA vaccines and therapeutics against a wide spectrum of diseases. We report the first...

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Cite This Study

Ahmed et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff39dd674f7c03778c636 https://doi.org/10.1039/d5dd00417a

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Soft sensor based on pH for real-time monitoring of mRNA medicines production

Key Points

Implication

Abstract

Discussion

Cite This Study

Soft sensor based on pH for real-time monitoring of mRNA medicines production

Key Points

Implication

Abstract

Discussion

Cite This Study

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