Comparative study evaluates carbapenemase detection in Enterobacteriaceae, suggesting reliable diagnostic methods.
BACKGROUND: This study aimed to evaluate the application of carbapenemase inhibitor and NG-test CARBA5 in the detection of carbapenemase genotype for Enterobacteriaceae. METHODS: We collected non-repetitive CRE (carbapenem-resistant Enterobacterales) isolated from patients at the Affiliated Cancer Hospital of Zhengzhou University in 2022. The carbapenemase type and gene type were detected by carbapenemase inhibitor test and NG-test CARBA5 assay, respectively. RESULTS: Sensitivity and specificity of the carbapenemase inhibitor test detecting five common carbapenemases were 100.00% and 98.36%, respectively. Sensitivity and specificity of NG-test CARBA5 were 95.90% and 99.18%, respectively. CONCLUSIONS: The carbapenemase inhibitor test and NG-test CARBA5 showed high sensitivity and specificity in detecting carbapenemase of Enterobacteriaceae.
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Wang et al. (2026) studied this question.
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