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May 22, 2026Transfusion

A case–control study of blood group antigen expression in Babesia microti infected patients in the United States

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Authors

RJRyan P. JajoskyBrigham and Women's HospitalMAMatthew AdjodhaMayo ClinicEBEmma L. BerdanHarvard University

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Implication

Case-control study investigates blood group antigen links to Babesia microti infection, suggesting further exploration is needed.

Key Points

  • This study investigates the relationship between blood group antigens and Babesia microti infection in human patients.
  • Conducted a case-control study with 200 patient samples from a national reference laboratory (June to August 2025).
  • Performed ABO and D phenotyping along with red blood cell genotyping of 37 antigens.
  • Analyzed PCR+ human patient samples for associations with blood group antigens.
  • Identified an odds ratio of 2.125 (95% CI 1.18-3.78, p = .015) suggesting a link between blood types and B. microti infection.
  • Observed two B. microti+ patients with the Fy(a-b-) phenotype, indicating Duffy's limited role as an invasion receptor.
  • No significant differences were found in ABO or D expression between infected and control groups.

Cite This Study

Jajosky et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff39dd674f7c03778c6cchttps://doi.org/10.1111/trf.70272
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