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May 22, 2026PLoS MedicineOpen Access

Associations between hematologic dynamics during pregnancy and obstetric complications: A retrospective observational study

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Authors

VTVeronica TozzoRPRachel PetherbridgeKJKaitlyn James

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Overview

Retrospective study examines hematologic changes in pregnancy and their impact on complications in women.

Key Points

  • This research aims to define typical changes in complete blood count during pregnancy and their associations with obstetric complications.
  • Retrospective observational study of 45,992 pregnancies from 1998–2016 and 48,868 from 2016–2024.
  • Analyzed nine CBC indices and developed gestational-age-specific reference intervals.
  • Tested associations between extreme CBC values and a composite outcome of obstetric complications using generalized estimating equations.
  • Hematocrit, hemoglobin, and red cell count outside the reference intervals were linked to increased risks: ORs of 1.4 for hematocrit and 1.6 for hemoglobin and red cell count (p<0.0001).
  • Extreme increases in hemoglobin and red cell count correlated with higher risks of preterm birth: ORs of 1.9 and 2.1, respectively (p<0.0001).

Cite This Study

Tozzo et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3d9d674f7c03778cb06https://doi.org/10.1371/journal.pmed.1004747
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