Substituent Effects on Photoresponsive Nitric Oxide Release by N -Nitrosoaniline Derivatives

Haruka Tsuchiya; Osuke Yoshikawa; Mei Harada; Mikako Ogawa; Yuhei Ohta; Hidehiko Nakagawa; Naoya Ieda

doi:10.1039/d6ob00679e

January 1, 2026Organic & Biomolecular ChemistryOpen Access

Substituent Effects on Photoresponsive Nitric Oxide Release by N -Nitrosoaniline Derivatives

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Key Points

The aim is to investigate how different substituents affect the release of nitric oxide from N-nitrosoaniline derivatives.
Synthesized various N-nitrosoaniline derivatives with different substituents.
Assessed nitric oxide release under light exposure using spectroscopic techniques.
Analyzed the biological effects of the released nitric oxide on vasorelaxation.
Photocontrollable NO release was significantly enhanced in derivatives with specific substituents.
Demonstrated effective vasorelaxation in model systems, indicating therapeutic potential.
Quantitative data showed a direct relationship between substituent characteristics and NO release efficiency.

Implication

Explores photoresponsive nitric oxide release in N-nitrosoaniline derivatives, suggesting innovative therapeutic applications.

Abstract

Nitric oxide (NO) is a short-lived signaling molecule mediating physiological functions such as vasorelaxation, and photocontrollable NO releasers that enable precise spatiotemporal control of NO release are useful tools for...

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Cite This Study

Tsuchiya et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3d9d674f7c03778cc52 https://doi.org/10.1039/d6ob00679e

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Substituent Effects on Photoresponsive Nitric Oxide Release by N -Nitrosoaniline Derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

Substituent Effects on Photoresponsive Nitric Oxide Release by N -Nitrosoaniline Derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

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