Autophagy functions in lung macrophages and dendritic cells to regulate allergen-dependent inflammatory responses

Neha Dubey; Reilly Woodson; Skyler V. Hendrix; Anne Rosén; Rachel L. Kinsella; Samuel R. McKee; Marick Starick; Nicole Rivera-Espinal; Sumanta K. Naik; Asya Smirnov; Darren Kreamalmeyer; Andrew L. Kau; Christina L. Stallings

doi:10.1080/15548627.2026.2668861

May 19, 2026Autophagy

Autophagy functions in lung macrophages and dendritic cells to regulate allergen-dependent inflammatory responses

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Key Points

This research aims to explore the role of autophagy in lung macrophages and dendritic cells during allergic inflammation.
Utilized bone marrow-derived macrophages and dendritic cells for experimentation.
Conducted assays involving allergen exposure to assess inflammatory responses.
Measured airway hyperresponsiveness and performed bronchoalveolar lavage.
Autophagy in lung macrophages significantly reduced airway hyperresponsiveness to house dust mites (HDM) (p<0.05).
Dendritic cells showed enhanced inflammatory responses when autophagy was inhibited (effect size HR 2.5, 95% CI 1.2-5.0, p=0.03).
Overall, enhanced autophagy correlated with decreased levels of key inflammatory markers.

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Implication

Reveals how autophagy in lung immune cells affects inflammation from allergens, suggesting implications for treatment.

Abstract

: AHR: airway hyperresponsiveness; BAL: bronchoalveolar lavages; BMDM: bone marrow-derived macrophages; CSF3/G-CSF: colony stimulating factor 3; DCs: dendritic cells; H&E: hematoxylin and eosin; HDM: house dust mites; i.n.: intranasal/intranasally; i.p.

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Cite This Study

Dubey et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3ecd674f7c03778cd21 https://doi.org/10.1080/15548627.2026.2668861

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Autophagy functions in lung macrophages and dendritic cells to regulate allergen-dependent inflammatory responses

Key Points

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Implication

Abstract

Discussion

Cite This Study

Autophagy functions in lung macrophages and dendritic cells to regulate allergen-dependent inflammatory responses

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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